含氯农药作为线粒体呼吸链抑制剂的活性评估。
Evaluation of the activity of chlorine-containing pesticides as inhibitors of the mitochondrial respiratory chain.
作者信息
Shabarchin E I, Panasenko O M, Kruglyakova K E
出版信息
Biol Bull Acad Sci USSR. 1979 Jan-Feb;6(1):101-6.
The influence of chlorine-containing pesticides, which are representatives of various classes of chemical compounds and possess various pesticidal activities, on the NAD . H oxidase activity of the submitochondrial particles (SMP) obtained from beef heart was studied. It was found that the strongest inhibitors of NAD . H oxidase of the SMP are chloro-derivatives of aromatic hydrocarbons (DDT and its analogs DDD and DDE). Derivatives of propionic and acetic acids (propinate, dalapon, MCAA, DCAA, and TCAA) did not exhibit any appreciable inhibiting effect under the experimental conditions. Criteria were introduced (phi and Ca50) permitting a quantitative characterization of the influence of pesticides on the respiratory chain of the mitochondria. Indications were obtained of possible mechanisms of the inhibiting action of the pesticides used.
研究了作为各类化合物代表且具有多种杀虫活性的含氯农药对从牛心获得的亚线粒体颗粒（SMP）的NAD.H氧化酶活性的影响。发现SMP的NAD.H氧化酶的最强抑制剂是芳烃的氯衍生物（滴滴涕及其类似物滴滴滴和滴滴伊）。在实验条件下，丙酸和乙酸的衍生物（丙酸盐、茅草枯、一氯乙酸、二氯乙酸和三氯乙酸）未表现出任何明显的抑制作用。引入了标准（φ和Ca50）以定量表征农药对线粒体呼吸链的影响。获得了所用农药抑制作用可能机制的迹象。
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