Picano E, Abbracchio M P
Italian National Research Council CNR, Institute of Clinical Physiology, Pisa, Italy.
Trends Pharmacol Sci. 1998 Jan;19(1):14-6. doi: 10.1016/s0165-6147(97)01148-6.
In patients with prior stroke or transient ischaemic attack, anti-platelet treatment with dipyridamole substantially reduced stroke recurrence, with a beneficial effect comparable to and additive with that induced by aspirin (the European Stroke Prevention Study-2). Eugenio Picano and Maria Abbracchio present here a platelet-independent hypothesis, according to which cardiovascular and neuroprotective actions achieved by dipyridamole through chronic elevation of endogenous adenosine levels may have contributed to the therapeutic success of this study.
在既往有中风或短暂性脑缺血发作的患者中，双嘧达莫抗血小板治疗可显著降低中风复发率，其有益效果与阿司匹林相当且具有相加作用（欧洲中风预防研究-2）。尤金尼奥·皮卡诺和玛丽亚·阿布拉乔在此提出了一个不依赖血小板的假说，根据该假说，双嘧达莫通过长期升高内源性腺苷水平所实现的心血管和神经保护作用可能促成了这项研究的治疗成功。
