Herabutya Y, O-Prasertsawat P
Department of Obstetrics and Gynaecology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Int J Gynaecol Obstet. 1998 Feb;60(2):161-5. doi: 10.1016/s0020-7292(97)00244-0.
To find the effective dose of intravaginal misoprostol to induce second trimester abortion.
Intravaginal misoprostol in 200-microg, 400-microg and 600-microg doses were applied at 12-h intervals in 150 consecutive pregnancies.
The 48-h successful abortion rate was 70.6%, 82% and 96%, respectively, and these rates were unaffected by parity. The mean induction to abortion interval was 45.0 +/- 41.5, 33.4 +/- 34.9 and 22.3 +/- 14.3 h, respectively. The mean dose of misoprostol required to induce abortion was 416.7 microg, 772.8 microg and 1296 microg. The rate of nausea and vomiting was 3.9%, 12% and 20%. The diarrhea occurrence rate was 0%, 6% and 22% with temperature elevation 0%, 2% and 28%, respectively. The rate of incomplete abortion was 35.3%, 28% and 22%, respectively.
The 600-microg dose is more effective as an abortifacient agent for second trimester abortion in terms of 48-h success rate and the rate of incomplete abortion but with more side effects. However, the side effects were mild and did not warrant any specific treatment.
探寻阴道内使用米索前列醇诱导中期妊娠流产的有效剂量。
对150例连续妊娠患者每隔12小时分别阴道内给予200微克、400微克和600微克剂量的米索前列醇。
48小时成功流产率分别为70.6%、82%和96%，这些比率不受产次影响。平均引产至流产间隔时间分别为45.0±41.5小时、33.4±34.9小时和22.3±14.3小时。诱导流产所需米索前列醇的平均剂量分别为416.7微克、772.8微克和1296微克。恶心呕吐发生率分别为3.9%、12%和20%。腹泻发生率分别为0%、6%和22%，体温升高发生率分别为0%、2%和28%。不全流产率分别为35.3%、28%和22%。
就48小时成功率和不全流产率而言，600微克剂量作为中期妊娠流产的堕胎药更有效，但副作用更多。然而，副作用较轻，无需特殊治疗。
