孕中期使用阴道内米索前列醇进行堕胎。

Second trimester abortion using intravaginal misoprostol.

作者信息

Herabutya Y, O-Prasertsawat P

机构信息

Department of Obstetrics and Gynaecology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Int J Gynaecol Obstet. 1998 Feb;60(2):161-5. doi: 10.1016/s0020-7292(97)00244-0.

DOI:10.1016/s0020-7292(97)00244-0

PMID:9509955

Abstract

OBJECTIVE

To find the effective dose of intravaginal misoprostol to induce second trimester abortion.

METHODS

Intravaginal misoprostol in 200-microg, 400-microg and 600-microg doses were applied at 12-h intervals in 150 consecutive pregnancies.

RESULTS

The 48-h successful abortion rate was 70.6%, 82% and 96%, respectively, and these rates were unaffected by parity. The mean induction to abortion interval was 45.0 +/- 41.5, 33.4 +/- 34.9 and 22.3 +/- 14.3 h, respectively. The mean dose of misoprostol required to induce abortion was 416.7 microg, 772.8 microg and 1296 microg. The rate of nausea and vomiting was 3.9%, 12% and 20%. The diarrhea occurrence rate was 0%, 6% and 22% with temperature elevation 0%, 2% and 28%, respectively. The rate of incomplete abortion was 35.3%, 28% and 22%, respectively.

CONCLUSION

The 600-microg dose is more effective as an abortifacient agent for second trimester abortion in terms of 48-h success rate and the rate of incomplete abortion but with more side effects. However, the side effects were mild and did not warrant any specific treatment.

摘要

目的

探寻阴道内使用米索前列醇诱导中期妊娠流产的有效剂量。

方法

对150例连续妊娠患者每隔12小时分别阴道内给予200微克、400微克和600微克剂量的米索前列醇。

结果

48小时成功流产率分别为70.6%、82%和96%，这些比率不受产次影响。平均引产至流产间隔时间分别为45.0±41.5小时、33.4±34.9小时和22.3±14.3小时。诱导流产所需米索前列醇的平均剂量分别为416.7微克、772.8微克和1296微克。恶心呕吐发生率分别为3.9%、12%和20%。腹泻发生率分别为0%、6%和22%，体温升高发生率分别为0%、2%和28%。不全流产率分别为35.3%、28%和22%。