Martin W, Müller M
Institut für Genetik, Technische Universität Braunschweig, Germany.
Nature. 1998 Mar 5;392(6671):37-41. doi: 10.1038/32096.
A new hypothesis for the origin of eukaryotic cells is proposed, based on the comparative biochemistry of energy metabolism. Eukaryotes are suggested to have arisen through symbiotic association of an anaerobic, strictly hydrogen-dependent, strictly autotrophic archaebacterium (the host) with a eubacterium (the symbiont) that was able to respire, but generated molecular hydrogen as a waste product of anaerobic heterotrophic metabolism. The host's dependence upon molecular hydrogen produced by the symbiont is put forward as the selective principle that forged the common ancestor of eukaryotic cells.
基于能量代谢的比较生物化学，提出了一种关于真核细胞起源的新假说。该假说认为，真核生物是通过一种厌氧的、严格依赖氢气的、严格自养的古细菌（宿主）与一种能够进行呼吸作用，但将分子氢作为厌氧异养代谢废物产生的真细菌（共生体）的共生结合而产生的。宿主对共生体产生的分子氢的依赖被提出作为塑造真核细胞共同祖先的选择原则。
