[Clinical effects of a clonidine-chlorthalidone combination in the treatment of arterial hypertension].
作者信息
Antonello A, Campanini M, Glorioso S, Borsatti A, Todesco S
出版信息
Minerva Med. 1976 Jul 21;67(35):2273-81.
PMID:951049
Abstract
Clonidine (0.075-0.225 mg/day) and chlorthalidone (0.15-0.45 mg/day) were associated in the management of 23 cases of arterial hypertension of varying nature and gravity. A significant and satisfactory decrease in pressure was accompanied by reduced cardiac frequency. Diuresis, body weight and the main biohumoral indices were not significantly affected. The mechanism of action of the two drugs is explained and the reason why success was obtained with their combination in less-than-normal doses is discussed.
摘要
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