Salgarello M C, Marchioro F, Bastianello D
Clinica Oncoematologica Pediatrica, Dipartimento di Pediatria, Padova.
Riv Inferm. 1997 Oct-Dec;16(4):201-14.
Mucositis are a common problem in patients undergoing active treatment: oral complications can be painful, impact on quality of life and contribute to significant compliance problems that may require suspension of the treatments. There is no agreement on oral care prevention and treatment protocols and on the scientific bases of the measures recommended. Seventy articles published from 1980 to 1996 were identified using the key-words mucositis, antineoplastic agents, chemotherapy and radiotherapy and 42 double-blind clinical trials were selected and analysed. The limitedness of sample sizes, the heterogeneity of patients' treatments (chemo and radiotherapy, different dosages and drugs) and oral care protocols (frequency of oral care, products used), the differences in evaluation scales used and in the outcomes selected (effect on pain, number of ulcers, severity of ulcers) did not allow to compare studies, and therefore to arrive to a consensus on the effectiveness of the treatments studied. Unfortunately, to date, there are no solutions to such a problem and, once the mucositis occurs, the best results can be obtained only on pain control.
口腔并发症可能会很疼痛，影响生活质量，并导致严重的依从性问题，可能需要暂停治疗。在口腔护理预防和治疗方案以及推荐措施的科学依据方面尚无共识。使用关键词“口腔黏膜炎”“抗肿瘤药物”“化疗”和“放疗”检索出了1980年至1996年发表的70篇文章，并选取和分析了42项双盲临床试验。样本量有限、患者治疗方式（化疗和放疗、不同剂量和药物）以及口腔护理方案（口腔护理频率、使用的产品）的异质性、所使用评估量表和所选结果（对疼痛的影响、溃疡数量、溃疡严重程度）的差异使得无法对研究进行比较，因此无法就所研究治疗方法的有效性达成共识。不幸的是，迄今为止，对于这样一个问题尚无解决方案，一旦发生口腔黏膜炎，只能在疼痛控制方面取得最佳效果。
