Savarino L, Stea S, Ciapetti G, Granchi D, Donati M E, Cervellati M, Visentin M, Moroni A, Pizzoferrato A
Laboratory for Biocompatibility Research on Implant Materials, Istituti Ortopedici Rizzoli, Bologna, Italy.
J Biomed Mater Res. 1998 Apr;40(1):86-91. doi: 10.1002/(sici)1097-4636(199804)40:1<86::aid-jbm10>3.0.co;2-i.
The in vivo compatibility and degradation aspects of an innovative coating to be sprayed onto titanium implants were investigated. The surface of fluorinated apatite (fHA), consisting of fluorhydroxyapatite plasma sprayed in a vacuum atmosphere, was treated with carbonate to improve its biological compatibility. fHA coating was compared with titanium implants coated (a) with hydroxyapatite (HA) by the traditional plasma spraying, and (b) with titanium oxide (TiOx). Screw-shaped implants were inserted in the cortical bone of sheep tibiae. X-ray diffraction (XRD) analysis of bone tissue and coatings was carried out at 2, 4, 12 and 36 weeks after surgery. The crystallographic habit of the implant-facing bone, as well as the structural stability of the coating, were evaluated. For each time period and type of ceramic bone apatite lattice at the interface, no significantly different reference apatite lattice and no foreign peak were recorded. Two weeks after implantation, the bone at the interface was strongly unmineralized in all samples; after 4 weeks, poorly mineralized bone microareas decreased. At 12 weeks, the newly formed bone tissue at the interface with both the new coating and HA coating was shown to be fully mineralized; this crystallographic habit was retained at 36 weeks, when particle release from the tested material was lower compared to the controls. The XRD pattern of bone apatite surrounding the coating particles was unmodified. The innovative coating did not alter the mineralization process at the interface. It improved implant osteointegration, mainly due to a limited release of particles. Consequently, clinical performance of external fixation treatment could be improved by modifying the chemical composition of the implant surface.
研究了一种喷涂在钛植入物上的创新涂层的体内相容性和降解情况。由在真空气氛中等离子喷涂的氟羟基磷灰石组成的氟化磷灰石（fHA）表面，经碳酸盐处理以提高其生物相容性。将fHA涂层与通过传统等离子喷涂涂覆（a）羟基磷灰石（HA）和（b）氧化钛（TiOx）的钛植入物进行比较。将螺旋形植入物插入绵羊胫骨的皮质骨中。在手术后2、4、12和36周对骨组织和涂层进行X射线衍射（XRD）分析。评估了面向植入物的骨的晶体习性以及涂层的结构稳定性。对于每个时间段和界面处的陶瓷骨磷灰石晶格类型，未记录到明显不同的参考磷灰石晶格和外来峰。植入后两周，所有样品界面处的骨严重未矿化；4周后，矿化不良的骨微区减少。12周时，与新涂层和HA涂层界面处新形成的骨组织均显示完全矿化；在36周时保持了这种晶体习性，此时与对照相比，测试材料的颗粒释放较低。涂层颗粒周围骨磷灰石的XRD图谱未改变。这种创新涂层未改变界面处的矿化过程。它改善了植入物的骨整合，主要是由于颗粒释放有限。因此，通过改变植入物表面的化学成分可以改善外固定治疗的临床性能。
