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[癫痫单一疗法的优化(临床药理学研究)]

[Optimisation of epilepsy monotherapy (clinico-pharmacological study)].

作者信息

Gromov S A, Khorshev S K

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 1997;97(7):31-5.

PMID:9511212
Abstract

The effect of four preparations (benzonal, phenobarbital, diphenyn, finlepsin), were examined in 214 epileptic patients with different forms of the fits. The advantages of monotherapy of epilepsy were grounded and therapeutic possibilities of the drugs were considered by means of clinico-pharmacological study. Standard and intensive methods of treatment of different forms of the fits were considered. It is demonstrated that maximal usage of therapeutic possibilities of the drugs resulted in the increase of the efficiency of treatment 2.5-fold. Daily doses and blood levels of the preparations were elevated, respectively. The term of "pseudotherapy" is grounded.

摘要

对214例患有不同发作形式的癫痫患者,研究了四种制剂(苯佐那尔、苯巴比妥、地芬宁、苯乙妥因)的疗效。通过临床药理学研究,论证了癫痫单一疗法的优势,并探讨了这些药物的治疗可能性。考虑了治疗不同发作形式的标准和强化方法。结果表明,最大限度地利用药物的治疗可能性可使治疗效率提高2.5倍。制剂的日剂量和血药浓度分别升高。“假性治疗”这一术语有了依据。

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