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[实验动物静脉血栓形成的建模]

[Modeling of phlebothrombosis in experimental animals].

作者信息

Baeshko A A, Kriuchok A G, Rogov Iu I, Sysov A V, Markautsan P V, Rolevich A I

出版信息

Klin Khir. 1997(9-10):71-3.

PMID:9511344
Abstract

Phlebothrombosis model was elaborated in experiment. The thrombotic mass was obtained in vitro, mixing the blood of animal with thrombin. Retracted thrombus was injected by puncture into previously ligated segment of the dog's v. jugularis externa. The vein's preparation was studied up on 1, 3, 5, 7, 10th and 14th day. Up to 8-10 days the thrombus adherence to the vein wall is friable and it is possible to extract it with the help of balloon catheter. Endothelium desquamation was revealed starting from 3-5th day.

摘要

在实验中建立了静脉血栓形成模型。通过将动物血液与凝血酶混合在体外获得血栓块。将回缩的血栓通过穿刺注入到预先结扎的狗的颈外静脉段。在第1、3、5、7、10和14天对静脉制剂进行研究。在8 - 10天内,血栓与静脉壁的粘附是脆弱的,可以借助球囊导管将其取出。从第3 - 5天开始发现内皮剥脱。

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