光谱病理学

Spectral pathology.

作者信息

Zonios G, Cothren R, Crawford J M, Fitzmaurice M, Manoharan R, Van Dam J, Feld M S

机构信息

George R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge 02139-4307, USA.

出版信息

Ann N Y Acad Sci. 1998 Feb 9;838:108-15. doi: 10.1111/j.1749-6632.1998.tb08191.x.

DOI:10.1111/j.1749-6632.1998.tb08191.x

PMID:9511799

Abstract

We are investigating the use of optical spectroscopy (fluorescence, reflectance, Raman scattering) for detecting precancerous lesions in the mucosal linings of hollow organs. We present a morphological model for extracting quantitative pathological information from fluorescence spectra, using colonic dysplasia as an example. The potential of this technique in providing histological information in real time without the need for tissue removal is discussed.

摘要

我们正在研究利用光学光谱法（荧光、反射率、拉曼散射）来检测中空器官粘膜内衬中的癌前病变。我们以结肠发育异常为例，提出了一种从荧光光谱中提取定量病理信息的形态学模型。本文还讨论了该技术在无需组织切除即可实时提供组织学信息方面的潜力。