电休克治疗对药物治疗抵抗的重度内源性青少年抑郁症的疗效
Effects of electroconvulsive therapy in adolescents with severe endogenous depression resistant to pharmacotherapy.
作者信息
Strober M, Rao U, DeAntonio M, Liston E, State M, Amaya-Jackson L, Latz S
机构信息
Department of Psychiatry & Biobehavioral Sciences, Neuropsychiatric Institute & Hospital, School of Medicine, University of California at Los Angeles 90024-1759, USA.
出版信息
Biol Psychiatry. 1998 Mar 1;43(5):335-8. doi: 10.1016/s0006-3223(97)00205-9.
BACKGROUND
This open, prospective study examined the effects of electroconvulsive therapy (ECT) in 10 adolescents with primary, endogenous, psychotic depression who were resistant to antidepressant pharmacotherapy.
METHODS
Change in symptom severity from baseline was assessed weekly with Hamilton Depression Rating Scale (HDRS) ratings, and outcome was measured additionally at 1 month, and again at 1 year, post-ECT.
RESULTS
All but 1 patient demonstrated dramatic improvement, with statistically significant decreases in mean HDRS score detected after the first week of treatment. All responders maintained the benefits of their treatment.
CONCLUSIONS
The results provide evidence of the clinical effectiveness of ECT in adolescents with phenomenological characteristics shown to be predictive of ECT response in adults.
背景
本开放性前瞻性研究考察了电休克治疗（ECT）对10例原发性内源性精神病性抑郁症青少年患者的疗效，这些患者对抗抑郁药物治疗无效。
方法
每周用汉密尔顿抑郁量表（HDRS）评分评估症状严重程度自基线的变化，并在ECT治疗后1个月和1年再次测量结局。
结果
除1例患者外，所有患者均有显著改善，治疗第一周后平均HDRS评分有统计学意义的下降。所有有反应者均维持了治疗效果。
结论
结果证明ECT对具有在成人中显示可预测ECT反应的现象学特征的青少年具有临床疗效。
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