Anuradha C V, Balakrishnan S D
Department of Biochemistry, Annamalai University, Nagar.
Indian J Physiol Pharmacol. 1998 Jan;42(1):64-70.
The effect of training on lipid peroxidation, thiol-status and certain antioxidant enzymes of glutathione system was studied in blood and tissues such as liver and skeletal muscle of rats. Exercise training was given by subjecting the rats to treadmill running. Training for a period of 6 weeks resulted in increased lipid peroxidation (P < 0.001) as indicated by thiobarbituric acid test and conjugated diene measurement in liver and muscle. Thiol levels (total and non-protein) were reduced. However, glutathione level in blood was increased and blood lipid peroxides were unaltered as a result of training compared to sedentary controls. Adaptive increases in three antioxidant enzyme activities were observed. The study indicates that training induces adaptation in the glutathione system.
研究了训练对大鼠血液以及肝脏和骨骼肌等组织中脂质过氧化、硫醇状态和谷胱甘肽系统某些抗氧化酶的影响。通过让大鼠在跑步机上跑步进行运动训练。为期6周的训练导致脂质过氧化增加（P < 0.001），这通过肝脏和肌肉中的硫代巴比妥酸试验和共轭二烯测量得以表明。硫醇水平（总硫醇和非蛋白质硫醇）降低。然而，与久坐不动的对照组相比，训练使血液中的谷胱甘肽水平升高，且血脂过氧化物未发生变化。观察到三种抗氧化酶活性的适应性增加。该研究表明训练可诱导谷胱甘肽系统产生适应性变化。
