Bardazzi G, Mannoni A, d'Albasio G, Bonanomi A G, Trallori G, Benucci M, Serni U, Pacini F
Gastroenterology Unit, Careggi Hospital, Florence, Italy.
Ital J Gastroenterol Hepatol. 1997 Dec;29(6):520-4.
Extraintestinal manifestations can complicate the course of ulcerative colitis and can influence the prognosis.
Sixty-eight patients of the metropolitan area of Florence with ulcerative colitis in clinical and endoscopic remission were evaluated to establish the presence of spondyloarthritis.
Each patient was studied through clinical and radiological evaluations to assess the presence of joint involvement.
We found signs of spondyloarthritis in 19 patients (27.9%). Four of them had a classic ankylosing spondylitis (5.8%) and in 3 of them the aplotype HLA B27 was present. Sacroileitis was found in 9 (13.2%) patients (monolateral in 5 cases and bilateral in 4). Six patients (8.8%) showed an unclassifiable form of arthritis, fulfilling the Amor criteria. In 13 of 19 patients with spondyloarthritis, we found a pancolic extension of disease (68.4%).
The results obtained from our series of ulcerative colitis patients reveal a lower proportion of cases of spondyloarthritis than that found in other Italian studies. We are planning further investigations on a larger population to better assess the prevalence of spondyloarthritis in ulcerative colitis patients.
肠外表现可使溃疡性结肠炎病情复杂化，并可影响预后。
对佛罗伦萨市区68例临床和内镜检查处于缓解期的溃疡性结肠炎患者进行评估，以确定是否存在脊柱关节炎。
对每位患者进行临床和影像学评估，以评估关节受累情况。
我们在19例患者（27.9%）中发现了脊柱关节炎的体征。其中4例患有典型的强直性脊柱炎（5.8%），3例存在HLA B27单倍型。9例（13.2%）患者发现骶髂关节炎（5例为单侧，4例为双侧）。6例（8.8%）患者表现为不符合分类标准的关节炎，符合Amor标准。在19例脊柱关节炎患者中，13例（68.4%）疾病呈全结肠扩展。
我们对溃疡性结肠炎患者系列研究的结果显示，脊柱关节炎病例比例低于其他意大利研究。我们正计划对更多人群进行进一步研究，以更好地评估溃疡性结肠炎患者中脊柱关节炎的患病率。
