高乙醇选择和低乙醇选择小鼠品系对C3醇的选择及其对旷场活动的影响。

Selection of C3 alcohols by high and low ethanol selecting mouse strains and the effects on open field activity.

作者信息

Strange A W, Goldbort R, Golbort R

出版信息

Pharmacol Biochem Behav. 1976 May;4(5):527-30. doi: 10.1016/0091-3057(76)90192-1.

Abstract

Mice of the high-ethanol selecting C57BL/6j strain consume significantly larger amounts of 10% solution of 1,2-propanediol and 1-propanol than the low-ethanol selecting DBA/2j strain. Both strains uniformly avoid a 10% solution of 1,3-propanediol and 2-propanol. Open field activity was tested 30 min after an IP injection of 3 different equimolar doses of each alcohol. An increase in activity was produced in the DBA/2j strain by high (0.003 ml/mg) and middle (0.0015 ml/lg) doses of 1,2-propanediol and by a low dose (0.0005 ml/mg) of 2-propanol. The C57BL/6j strain were unaffected by these doses. High doses of 2-propanol produced sleep in both strains with the DBA/2j strain sleeping significantly longer, and 1,3-propanediol produced depression in both strains. Death resulted in all animals following injections at the high (0.002 mg/gm) and medium (0.001 ml/gm) doses of 1-propanol while the low dose (0.0005 ml/gm) produced slight depression.

摘要

与低乙醇选择的DBA/2j品系小鼠相比，高乙醇选择的C57BL/6j品系小鼠消耗的1,2 - 丙二醇和1 - 丙醇的10%溶液量显著更多。两个品系的小鼠都一致避免饮用1,3 - 丙二醇和2 - 丙醇的10%溶液。在腹腔注射三种不同等摩尔剂量的每种酒精30分钟后，测试旷场活动。高剂量（0.003 ml/mg）和中等剂量（0.0015 ml/lg）的1,2 - 丙二醇以及低剂量（0.0005 ml/mg）的2 - 丙醇使DBA/2j品系小鼠的活动增加。这些剂量对C57BL/6j品系小鼠没有影响。高剂量的2 - 丙醇使两个品系的小鼠都入睡，其中DBA/2j品系小鼠的睡眠时间显著更长，而1,3 - 丙二醇使两个品系的小鼠都出现抑郁。高剂量（0.002 mg/gm）和中等剂量（0.001 ml/gm）的1 - 丙醇注射后所有动物死亡，而低剂量（0.0005 ml/gm）则产生轻微抑郁。