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Formation of hydroxyfuranone and hydroxypyranone derivatives with DNA-breaking activity in the Maillard reaction of glucose and albumin under physiological conditions.

作者信息

Hiramoto K, Ishihara A, Sakui N, Daishima S, Kikugawa K

机构信息

School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan.

出版信息

Biol Pharm Bull. 1998 Feb;21(2):102-4. doi: 10.1248/bpb.21.102.

DOI:10.1248/bpb.21.102
PMID:9514600
Abstract

Formation of DNA breaking hydroxyfuranone and hydroxypyranone derivatives in the Maillard reaction of glucose and bovine serum albumin (BSA) under physiological conditions was investigated. A mixture of glucose and BSA was incubated at 37 degrees C in water or in 1 M phosphate buffer (pH 7.4). The ethyl acetate/2-propanol extract of the reaction mixtures showed significant DNA breaking activity against supercoiled DNA especially in the presence of Fe(III) ion. Gas chromatography/mass spectrometry analysis of the mixture revealed the formation of DNA breaking hydroxyfuranones (HMF and DMHF) and hydroxypyranone (DDMP).

摘要

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