Bounameaux H
Département de médecine interne, hôpitaux universitaires de Genève, Suisse.
Rev Med Interne. 1997;18 Suppl 6:606s-612s. doi: 10.1016/s0248-8663(97)80706-0.
The presence of D-dimers in the bloodstream is secondary to fibrin formation and lysis. Because fibrin is the main component of a thrombus, deep vein thrombosis and/or pulmonary embolism may be excluded with a predictive value of more than 95%, provided D-dimer plasma concentration is below a critical, assay-dependent cutoff. The D-dimer test is thus an ideal screening step in outpatients clinically suspected of venous thromboembolism. Only ELISA tests have been validated in clinical practice at present time for this indication, sensitivity of latex assays being insufficient.
血液中D - 二聚体的存在继发于纤维蛋白的形成和溶解。由于纤维蛋白是血栓的主要成分，若D - 二聚体血浆浓度低于一个取决于检测方法的临界值，则深静脉血栓形成和/或肺栓塞的排除预测值可超过95%。因此，D - 二聚体检测是临床怀疑静脉血栓栓塞症的门诊患者理想的筛查步骤。目前只有ELISA检测在临床实践中针对该适应症得到验证，乳胶检测的灵敏度不足。
