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[感染性心内膜炎患者的霉菌性动脉瘤和多发性外周栓塞]

[Mycotic aneurysms and multiple peripheral embolisms in a patient with infectious endocarditis].

作者信息

Mertens R, Krämer A, Valdés F, Garayar B, Irarrázaval M

机构信息

Departamento de Enfermedades Cardiovasculares, Facultad de Medicina, Pontificia Universidad Católica de Chile.

出版信息

Rev Med Chil. 1997 Jun;125(6):696-700.

PMID:9515290
Abstract

Sepsis from an infected cardiac valve can lead to bacterial seeding and destruction of the arterial wall with formation of a mycotic aneurysm. The natural history of these lesions is the rupture. We report the case of a 20 year old female who was admitted to our institution with massive mitral regurgitation and emboli of the central nervous system and both lower extremities. She underwent emergency valve replacement and then, staged treatment of her ischemic legs and multiple asymptomatic mycotic aneurysms: Superior mesenteric, right common iliac and left superficial femoral arteries. A splenectomy was required to treat a splenic abscess. An aneurysm of a peripheral branch of the middle cerebral artery was medically treated, demonstrating reduction in size on subsequent angiogram. She recovered uneventfully and remains asymptomatic after 20 months of follow up. The development of new diagnostic and therapeutic tools has led to a decrease of these complications during infectious endocarditis. However, in the patient with late diagnosis and symptoms in different territories, the mycotic aneurysm must be kept in mind to provide the patient with appropriate treatment.

摘要

感染性心脏瓣膜引起的脓毒症可导致细菌播散并破坏动脉壁,形成感染性动脉瘤。这些病变的自然转归是破裂。我们报告一例20岁女性患者,因大量二尖瓣反流及中枢神经系统和双下肢栓塞入住我院。她接受了急诊瓣膜置换术,随后分期治疗其缺血性下肢及多个无症状感染性动脉瘤:肠系膜上动脉、右髂总动脉和左股浅动脉。为治疗脾脓肿,行脾切除术。大脑中动脉外周分支的一个动脉瘤接受了药物治疗,后续血管造影显示其大小缩小。她恢复顺利,随访20个月后仍无症状。新诊断和治疗工具的发展已使感染性心内膜炎期间这些并发症有所减少。然而,对于诊断较晚且出现不同部位症状的患者,必须考虑感染性动脉瘤,以便为患者提供恰当治疗。

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