Ariad S, Rabinovitz A, Yanai-Inbar I, Piura B
Dept. of Oncology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheba.
Harefuah. 1998 Jan 15;134(2):93-6, 159.
During 1971-1996, 17 patients with mixed mesodermal uterine tumors were treated. Average age at diagnosis was 67.3 years, 12/17 were of European and 5/17 of Afro-Asian extraction. The overall 5-year survival was 21%. 10/17 patients had mixed mesodermal tumors with a heterologous mesenchymal element, and 7/17 had a homologous mesenchymal element (carcinosarcoma). 6/17 had another primary malignancy, including breast cancer (3/17), bilateral metachronous breast tumor (2/17), and malignant lymphoma of the neck region (2/17). All 3 with breast cancer had previously been treated with tamoxifen. I had simultaneous mesodermal tumor and ovarian thecoma. Simultaneous autoimmune manifestations occurred in 2/17, including thrombocytopenic purpura in 1, and myasthenia gravis in another. Mesodermal tumor of the uterus is a relatively rare malignancy with aggressive behavior and poor prognosis. It also had unusual associations with other primary tumors, hormonal treatment, and autoimmune manifestations.
1971年至1996年间，对17例混合性中胚层子宫肿瘤患者进行了治疗。诊断时的平均年龄为67.3岁，17例中有12例为欧洲裔，5例为亚非裔。总体5年生存率为21%。17例患者中有10例混合性中胚层肿瘤伴有异源性间充质成分，7例伴有同源性间充质成分（癌肉瘤）。17例中有6例患有另一种原发性恶性肿瘤，包括乳腺癌（17例中的3例）、双侧异时性乳腺肿瘤（17例中的2例）和颈部恶性淋巴瘤（17例中的2例）。所有3例乳腺癌患者此前均接受过他莫昔芬治疗。1例患者同时患有中胚层肿瘤和卵巢卵泡膜细胞瘤。17例中有2例出现同时性自身免疫表现，其中1例为血小板减少性紫癜，另1例为重症肌无力。子宫中胚层肿瘤是一种相对罕见的恶性肿瘤，具有侵袭性且预后较差。它还与其他原发性肿瘤、激素治疗和自身免疫表现存在不寻常的关联。
