溃疡性结肠炎患者核周抗中性粒细胞胞浆抗体状态的长期观察
Long-term observation of the perinuclear anti-neutrophil cytoplasmic antibody status in ulcerative colitis patients.
作者信息
Vecchi M, Bianchi M B, Calabresi C, Meucci G, Tatarella M, de Franchis R
机构信息
Dept. of Gastroenterology and Digestive Endoscopy, Institute of Internal Medicine, University of Milan, IRCCS Ospedale Policlinico di Milano, Italy.
出版信息
Scand J Gastroenterol. 1998 Feb;33(2):170-3. doi: 10.1080/00365529850166905.
BACKGROUND
Perinuclear anti-neutrophil cytoplasmic antibodies (p-ANCA) have been regarded as a possible immunogenetic marker of ulcerative colitis. If this were true, the p-ANCA status of a given patient should be constant over time; however, little information is available on this issue.
METHODS
One hundred and forty-five sera collected from 40 ulcerative colitis patients during a mean follow-up period of 50.6 months were tested for p-ANCA reactivity by indirect immunofluorescence.
RESULTS
At base line 24 patients (60%) were p-ANCA-positive, with no relationship to gender distribution, age at diagnosis, disease activity, or extension. During follow-up, changes in p-ANCA status occurred in 10 patients (25%). P-ANCA positivity during follow-up was associated with more aggressive forms of disease, whereas p-ANCA negativity was associated with stable remission.
CONCLUSIONS
Changes in the p-ANCA status over time occur in some ulcerative colitis patients. P-ANCA behaviour is associated with different clinical patterns of disease.
背景
核周型抗中性粒细胞胞浆抗体（p-ANCA）被视为溃疡性结肠炎可能的免疫遗传标志物。如果确实如此，特定患者的p-ANCA状态应随时间保持恒定；然而，关于这一问题的信息很少。
方法
对40例溃疡性结肠炎患者在平均50.6个月的随访期间收集的145份血清进行间接免疫荧光检测p-ANCA反应性。
结果
基线时24例患者（60%）p-ANCA阳性，与性别分布、诊断时年龄、疾病活动度或病变范围无关。随访期间，10例患者（25%）的p-ANCA状态发生变化。随访期间p-ANCA阳性与更严重的疾病形式相关，而p-ANCA阴性与病情稳定缓解相关。
结论
部分溃疡性结肠炎患者的p-ANCA状态随时间发生变化。P-ANCA的变化与不同的疾病临床类型相关。
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