Buffalo E A, Stefanacci L, Squire L R, Zola S M
Graduate Program in Neurosciences, University of California, San Diego, La Jolla 92037, USA.
Behav Neurosci. 1998 Feb;112(1):3-14. doi: 10.1037//0735-7044.112.1.3.
For 30 years, the concurrent discrimination learning task has figured prominently in studies used to determine the effects of medial temporal lobe damage in monkeys. However, the findings from these studies have been contradictory. We explored the contribution to concurrent discrimination performance of inadvertent damage to area TE by reexamining the behavioral data and histological material from monkeys with medial temporal lobe lesions previously tested in our laboratory. The amount of inadvertent damage to area TE was more predictive of impaired performance on the concurrent discrimination learning task than was the amount of damage to any medial temporal lobe structure, including the perirhinal cortex. These findings resolve earlier inconsistent findings regarding the concurrent discrimination learning task by demonstrating that performance on this task depends on area TE and not on perirhinal cortex or other medial temporal lobe structures.
30年来，并行辨别学习任务在用于确定猴子内侧颞叶损伤影响的研究中一直占据显著地位。然而，这些研究的结果相互矛盾。我们通过重新审视先前在我们实验室测试过的内侧颞叶损伤猴子的行为数据和组织学材料，探讨了颞下回（TE区）意外损伤对并行辨别表现的影响。与包括嗅周皮质在内的任何内侧颞叶结构的损伤量相比，颞下回（TE区）的意外损伤量更能预测并行辨别学习任务的表现受损。这些发现通过证明该任务的表现取决于颞下回（TE区）而非嗅周皮质或其他内侧颞叶结构，解决了早期关于并行辨别学习任务的不一致发现。
