Jennings P J, Janowsky J S, Orwoll E
Department of Neurology, Oregon Health Sciences University, Portland, USA.
Behav Neurosci. 1998 Feb;112(1):154-9. doi: 10.1037//0735-7044.112.1.154.
Normal movement depends in part on the brain's ability to produce and use dopamine, which regulates basal ganglia function. Behavioral, neuroanatomical, and neurophysiological data suggest that the basal ganglia are critical for the performance of sequential movement. Dopaminergic function is modulated by estrogen in animals and in humans. To test the hypothesis that estrogen modulates sequential movement, this study measured the reaction time (RT) and movement time (MT) of 15 women and 10 men in a choice RT task with sequential responses. Higher levels of estradiol in women's blood were associated with faster total movement time (RT plus MT). Testosterone levels in women's blood were not associated with keypressing performance. Hormone levels in men's blood were unrelated to keypressing performance. These results suggest that women's motor performance was affected by hormone levels, and that estrogen may interact with dopaminergic function in women.
正常运动部分取决于大脑产生和利用多巴胺的能力，多巴胺可调节基底神经节的功能。行为学、神经解剖学和神经生理学数据表明，基底神经节对于连续运动的执行至关重要。在动物和人类中，雌激素可调节多巴胺能功能。为了验证雌激素调节连续运动这一假说，本研究在一项具有连续反应的选择反应时任务中测量了15名女性和10名男性的反应时（RT）和运动时（MT）。女性血液中较高水平的雌二醇与更快的总运动时间（RT加MT）相关。女性血液中的睾酮水平与按键表现无关。男性血液中的激素水平与按键表现无关。这些结果表明，女性的运动表现受激素水平影响，并且雌激素可能与女性的多巴胺能功能相互作用。
