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[补骨脂素紫外线A光浴光化学疗法治疗连续性肢端脓疱病(Hallopeau型)]

[PUVA-bath photochemotherapy in Hallopeau's acrodermatitis continua suppurativa].

作者信息

Behrens S, von Kobyletzki G, Hoffmann K, Altmeyer P, Kerscher M

机构信息

Dermatologische Klinik, Ruhr-Universität Bochum.

出版信息

Hautarzt. 1997 Nov;48(11):824-7. doi: 10.1007/s001050050668.

Abstract

A 73-year-old man presented with severe, relapsing acrodermatitis continua of Hallopeau, which had been resistant to prior local and systemic therapy for eight years. The patient was treated with selective hand PUVA-bath photochemotherapy. The cumulative dose of UVA used over 10 weeks of treatment was 54.6 J/cm2 on the palms and 26.8 J/cm2 on the dorsum of the hands. The single UVA doses ranged from 0.5 to 2.5 J/cm2 on the palms and 0.2 to 1.4 J/cm2 on the dorsum of the hands. After 16 treatment sessions, the acrodermatitis continua started to improve, and after 24 treatments, had cleared completely. In the four months following the PUVA therapy, there was no relapse. PUVA-bath photochemotherapy is an efficient therapeutic alternative in the treatment of acrodermatitis continua due to its clinical effectiveness and lack of any systemic side effects. It also possesses the advantage of allowing selective photosensitization of certain areas of the skin such as the hands.

摘要

一名73岁男性患有严重的、复发性Hallopeau连续性肢端皮炎,此前接受局部和全身治疗八年均无效。该患者接受了选择性手部PUVA浴光化学疗法。在10周的治疗过程中,手掌的累积UVA剂量为54.6 J/cm2,手背为26.8 J/cm2。单次UVA剂量在手掌上为0.5至2.5 J/cm2,在手背为0.2至1.4 J/cm2。经过16次治疗后,连续性肢端皮炎开始改善,24次治疗后完全消退。在PUVA治疗后的四个月里,没有复发。由于其临床疗效和无任何全身副作用,PUVA浴光化学疗法是治疗连续性肢端皮炎的一种有效治疗选择。它还具有允许对皮肤的某些区域(如手部)进行选择性光敏化的优点。

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