Mao J B, Robinson J K
Department of Psychology, State University of New York at Stony Brook, New York, USA.
Brain Res. 1998 Feb 16;784(1-2):139-47. doi: 10.1016/s0006-8993(97)01324-3.
Anatomical studies of afferent and efferent connections suggest that the hippocampus may have more than one information processing role that varies along the septo-hippocampal axis. The present study was conducted to test whether a distinct functional specialization for the dorsal versus ventral extents of the hippocampus could be detected. The effects of a GABA-A receptor agonist, muscimol, microinjected into either the dorsal or ventral hippocampus on an operant, spatial delayed non-matching-to-position (DNMTP) task were measured. A decrease in the number of trials completed per session and disruption of several DNMTP discrimination parameters were produced by muscimol microinjection into the dorsal hippocampus but not into the ventral hippocampus. Muscimol injected into either site did not impair the measure of working memory, delayed choice accuracy. These results are consistent with the view that hippocampal function varies along the septo-temporal axis, and that the dorsal hippocampus is relatively more critical to visual discrimination performance than the ventral hippocampus.
对传入和传出连接的解剖学研究表明，海马体可能具有不止一种信息处理功能，且这些功能沿隔海马轴有所不同。本研究旨在测试是否能检测到海马体背侧和腹侧区域存在明显的功能特化。测量了将γ-氨基丁酸A（GABA-A）受体激动剂蝇蕈醇微量注射到海马体背侧或腹侧后，对操作性空间延迟位置匹配（DNMTP）任务的影响。向海马体背侧而非腹侧微量注射蝇蕈醇会导致每次实验完成的试验次数减少，并干扰多个DNMTP辨别参数。注射到任一部位的蝇蕈醇均未损害工作记忆指标，即延迟选择准确性。这些结果与以下观点一致：海马体功能沿隔颞轴变化，且海马体背侧对视觉辨别表现的作用相对比腹侧更为关键。
