Biopsy of the skin. Thoughtful selection of technique improves yield.

Skin biopsy can serve both diagnostic and therapeutic purposes. Site selection is not of major importance in the many types of lesions suggestive of malignancy but is crucial with diffuse eruptions. The shave technique is appropriate for many neoplastic lesions, while punch or incisional/excisional biopsy is necessary for more deeply invasive lesions. A variety of anesthetics are available to aid in patient comfort, as are a number of techniques for accomplishing the procedure to achieve the best cosmetic result.