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Hypothermia attenuates the activation of protein kinase C in focal ischemic rat brain: dual autoradiographic study of [3H]phorbol 12,13-dibutyrate and iodo[14C]antipyrine.

作者信息

Tohyama Y, Sako K, Yonemasu Y

机构信息

Department of Neurosurgery, Asahikawa Medical College, Japan.

出版信息

Brain Res. 1998 Jan 26;782(1-2):348-51. doi: 10.1016/s0006-8993(97)01180-3.

DOI:10.1016/s0006-8993(97)01180-3
PMID:9519286
Abstract

Using phorbol 12,13-dibutyrate (PDBu) autoradiography, we investigated the effect of hypothermia or protein kinase C (PKC) activation in rat brain 2 h after focal ischemia. In normothermia, a significant increase of PDBu binding was observed in ischemic brain. Hypothermia suppressed the increase of PDBu binding in degree and extent. These observations suggest that intraischemic hypothermia attenuates the activation of PKC, and this may in part be participate in the protective effect of hypothermia.

摘要

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