食物偏好的遗传变异及其对肥胖的影响。
Heritable variation in food preferences and their contribution to obesity.
作者信息
Reed D R, Bachmanov A A, Beauchamp G K, Tordoff M G, Price R A
机构信息
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA.
出版信息
Behav Genet. 1997 Jul;27(4):373-87. doi: 10.1023/a:1025692031673.
Abstract
What an animal chooses to eat can either induce or retard the development of obesity; this review summarizes what is known about the genetic determinants of nutrient selection and its impact on obesity in humans and rodents. The selection of macronutrients in the diet appears to be, in part, heritable. Genes that mediate the consumption of sweet-tasting carbohydrate sources have been mapped and are being isolated and characterized. Excessive dietary fat intake is strongly tied to obesity, and several studies suggest that a preference for fat and the resulting obesity are partially genetically determined. Identifying genes involved in the excess consumption of dietary fat will be an important key to our understanding of the genetic disposition toward common dietary obesity.
摘要
动物选择吃什么既可以诱发也可以延缓肥胖的发展；这篇综述总结了关于营养选择的遗传决定因素及其对人类和啮齿动物肥胖影响的已知情况。饮食中宏量营养素的选择似乎部分是可遗传的。介导甜味碳水化合物来源摄入的基因已被定位，并且正在被分离和表征。过量的膳食脂肪摄入与肥胖密切相关，几项研究表明对脂肪的偏好以及由此导致的肥胖部分是由基因决定的。识别与膳食脂肪过量摄入有关的基因将是我们理解常见膳食性肥胖遗传倾向的重要关键。
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