Kushelevsky A P, Harari M, Kudish A I, Hristakieva E, Ingber A, Shani J
Department of Nuclear Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
J Am Acad Dermatol. 1998 Mar;38(3):447-52. doi: 10.1016/s0190-9622(98)70504-3.
Climatotherapy at the Dead Sea is effective for patients with psoriasis, atopic dermatitis, vitiligo, and other diseases. Although impressive improvement has been reported for patients with psoriasis, with a clearance rate of more than 80% after a 4-week stay, questions regarding the safety of this treatment have arisen.
We compare the mean UVB radiation intensities absorbed by psoriatic patients undergoing a 4-week climatotherapy under supervision at the DMZ Rehabilitation Clinic of Ein-Bokek (The Dead Sea, Israel), with similar climatotherapy studies in Sweden and Switzerland. We also compare the climatotherapy radiation dosages with the UVB intensities absorbed by psoriatic patients in radiation cabins at seven university clinics.
According to our individually computerized DMZ protocol, a psoriasis patient with skin type IV is exposed during a 4-week climatotherapy to a mean 3.11 J/cm2 (148 MED) of UVB, similar to that in Sweden and Switzerland. The range of the in-clinic annual phototherapy in the seven medical centers studied varied from 1.17 to 37.80 J/cm2 (56 to 1800 MED).
When all relevant factors are taken into account, the mean UVB exposure dose at the Dead Sea is one of the lowest reported for clearance of psoriatic plaques.
死海气候疗法对银屑病、特应性皮炎、白癜风及其他疾病患者有效。尽管有报道称银屑病患者有显著改善，在停留4周后清除率超过80%，但这种治疗的安全性问题也随之出现。
我们将在以色列死海埃因-博凯克的DMZ康复诊所接受4周监督下气候疗法的银屑病患者所吸收的平均中波紫外线（UVB）辐射强度，与瑞典和瑞士的类似气候疗法研究进行比较。我们还将气候疗法的辐射剂量与七所大学诊所的辐射舱内银屑病患者所吸收的UVB强度进行比较。
根据我们个体化的计算机化DMZ方案，一名IV型皮肤的银屑病患者在4周气候疗法期间平均暴露于3.11 J/cm²（148最小红斑量）的UVB下，这与瑞典和瑞士的情况相似。在所研究的七个医疗中心，临床年度光疗范围从1.17至37.80 J/cm²（56至1800最小红斑量）不等。
综合考虑所有相关因素后，死海的平均UVB暴露剂量是已报道的清除银屑病斑块所需的最低剂量之一。
