Midtby M, Magnus J H
Revmatologisk avdeling, Universitetet i Tromsø.
Tidsskr Nor Laegeforen. 1998 Feb 10;118(4):552-7.
The skeleton is a metabolically active organ in constant change and renewal. Specialised cells are responsible for resorbing and synthetizing bone matrix. The process of bone remodelling, by removing old and damaged bone tissue and replacing it with new, is necessary for conserving the integrity of bone. In recent years, research has given new insight into the fine relationship between different cell types in bone tissue. This has enhanced our understanding of the pathophysiology behind osteoporosis and other metabolical bone diseases. This article gives a summary of our present knowledge of the normal cell biology of bone and what contributes to its regulation. How this helps the understanding of normal and pathological bone loss is illustrated. It is important to understand bone remodelling in order to interpret measurements of bone mineral density and biochemical markers accurately.
骨骼是一个处于不断变化和更新中的代谢活跃器官。特殊细胞负责吸收和合成骨基质。骨重塑过程通过去除旧的和受损的骨组织并以新的骨组织取而代之，对于维持骨骼的完整性是必要的。近年来，研究对骨组织中不同细胞类型之间的精细关系有了新的认识。这增进了我们对骨质疏松症和其他代谢性骨病背后病理生理学的理解。本文总结了我们目前对骨正常细胞生物学及其调节因素的认识。阐述了这如何有助于理解正常和病理性骨质流失。为了准确解读骨密度测量和生化标志物，了解骨重塑很重要。
