Iezzoni J C, Bruns M E, Frierson H F, Scott M G, Pence R A, Deftos L J, Bruns D E
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Mod Pathol. 1998 Mar;11(3):265-70.
Parathyroid hormone-related protein (PTHrP), the pathogenic factor in most cases of humoral hypercalcemia of malignancy, is also expressed by many normal tissues. Its diverse biologic activities in these tissues are mediated by the PTH/PTHrP receptor through autocrine and paracrine mechanisms. Recent data suggest that PTHrP and its receptor might also influence the growth and metastatic spread of some cancers through similar local actions. Accordingly, immunohistochemical studies using murine monoclonal antibodies to detect coexpression of PTHrP and the PTH/PTHrP receptor were performed on 52 invasive breast carcinomas to assess the existence of this potential autocrine effector system. All of the 52 invasive breast carcinomas expressed reactivity for PTHrP, and 50 (96%) of these tumors also expressed reactivity for the receptor. Although additional investigations are necessary for evaluation of the role of PTHrP and PTH/PTHrP receptor in tumor pathogenesis, our current study demonstrates the presence of this potential autocrine effector system in the great majority of invasive breast carcinomas.
甲状旁腺激素相关蛋白（PTHrP）是大多数恶性肿瘤体液性高钙血症病例中的致病因素，许多正常组织也会表达该蛋白。其在这些组织中的多种生物学活性是通过甲状旁腺激素/甲状旁腺激素相关蛋白受体（PTH/PTHrP受体），经自分泌和旁分泌机制介导的。最近的数据表明，PTHrP及其受体可能也通过类似的局部作用影响某些癌症的生长和转移扩散。因此，我们使用鼠单克隆抗体进行免疫组织化学研究，以检测PTHrP和PTH/PTHrP受体的共表达情况，对52例浸润性乳腺癌进行了检测，以评估这种潜在自分泌效应系统的存在情况。52例浸润性乳腺癌均对PTHrP呈反应性，其中50例（96%）肿瘤对该受体也呈反应性。尽管评估PTHrP和PTH/PTHrP受体在肿瘤发病机制中的作用还需要进一步研究，但我们目前的研究表明，绝大多数浸润性乳腺癌中存在这种潜在的自分泌效应系统。
