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[根据聚丙烯酰胺凝胶圆盘电泳分析神经系统疾病患儿脑脊液蛋白质的组成]

[Composition of cerebrospinal fluid protein in children with nervous system diseases according to disc-electrophoresis in polyacrylamide gel].

作者信息

Nesterovskiĭ E B

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1976;76(6):869-72.

PMID:952152
Abstract

The author studied the fractional content of proteins in the CSF in 105 children with different disorders of the nervous system and 35 children of a control group (aged 2-13 years) with the aid of disc-electrophoresis in polyacrylamide gel. The proteins of the CSF were studied in encephalitis, polyradiculoneuritis, cerebral arachnoiditis, brain tumors and epilepsy. The content of total proteins in the CSF in 42% of the studied children did not differ significantly from the usual age norm. More distinct changes were found in proteinogramms of the CSF where 14 protein fractions were singled out. It was established that a change in the content of separate fractions, their intercorrelation depended on the character of the pathological process.

摘要

作者借助聚丙烯酰胺凝胶圆盘电泳,研究了105名患有不同神经系统疾病的儿童以及35名对照组儿童(年龄在2至13岁之间)脑脊液中蛋白质的分数含量。对脑炎、多发性神经根神经炎、脑蛛网膜炎、脑肿瘤和癫痫患者的脑脊液蛋白质进行了研究。在42%的受试儿童中,脑脊液中总蛋白含量与正常年龄标准无显著差异。在脑脊液蛋白质图谱中发现了更明显的变化,其中分离出了14种蛋白质组分。已确定各组分含量的变化及其相互关系取决于病理过程的特征。

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