Ohtsuka T
Department of Dermatology, Dokkyo University School of Medicine, Tochigi, Japan.
Int J Dermatol. 1998 Jan;37(1):23-6. doi: 10.1046/j.1365-4362.1998.00313.x.
Patients with connective tissue diseases, mainly scleroderma, show nailfold bleeding and nailfold capillary abnormality. An attempt was made to determine the possible relation between nailfold bleeding and nailfold capillary abnormality.
The correlation between nailfold bleeding and nailfold capillary abnormality was studied using quantitative nailfold capillary microscopy.
The frequencies of nailfold bleeding in scleroderma, mixed connective tissue disease, dermatomyositis/polymyositis, and secondary Raynaud's phenomenon were significantly higher than those of normal controls. The distributions of abnormal values of capillary parameters in scleroderma, mixed connective tissue disease, dermatomyositis/polymyositis, systemic lupus erythematosus, primary Sjögren's syndrome, secondary Raynaud's phenomenon, primary Raynaud's phenomenon, and diabetes mellitus were significantly higher than those of normal controls. In normal controls, scleroderma, mixed connective tissue diseases, dermatomyositis/polymyositis, systemic lupus erythematosus, primary Sjögren's syndrome, primary Raynaud's phenomenon, and diabetes mellitus, all nailfold bleeding was observed in subjects with nailfold capillary abnormality. The distribution of nailfold bleeding in secondary Raynaud's phenomenon with abnormal values of capillary parameters was significantly higher than that with normal values.
There is a close relationship between nailfold bleeding and nailfold capillary abnormality.
结缔组织病患者，主要是硬皮病患者，表现出甲襞出血和甲襞毛细血管异常。本研究旨在确定甲襞出血与甲襞毛细血管异常之间的可能关系。
采用定量甲襞毛细血管显微镜检查研究甲襞出血与甲襞毛细血管异常之间的相关性。
硬皮病、混合性结缔组织病、皮肌炎/多肌炎和继发性雷诺现象患者的甲襞出血频率显著高于正常对照组。硬皮病、混合性结缔组织病、皮肌炎/多肌炎、系统性红斑狼疮、原发性干燥综合征、继发性雷诺现象、原发性雷诺现象和糖尿病患者的毛细血管参数异常值分布显著高于正常对照组。在正常对照组、硬皮病、混合性结缔组织病、皮肌炎/多肌炎、系统性红斑狼疮、原发性干燥综合征、原发性雷诺现象和糖尿病患者中，所有甲襞出血均见于甲襞毛细血管异常的患者。毛细血管参数异常的继发性雷诺现象患者的甲襞出血分布显著高于参数正常者。
甲襞出血与甲襞毛细血管异常之间存在密切关系。
