Hirsch J, Leibel R L
Rockefeller University, New York, USA.
Hosp Pract (1995). 1998 Mar 15;33(3):55-9, 62-5, 69-70 passim. doi: 10.1080/21548331.1998.11443653.
Five genes have been identified, each capable of causing obesity in mice and each with a human homologue. One of them codes for a signal expressed by adipose tissue, and another for the signal's brain receptor. The rest reveal brain pathways probably downstream from the receptor. Together, the genes offer glimpses of an intricate system that defends adipose stores--and in some persons maintains an unhealthful set-point.
已经鉴定出五个基因，每个基因都能在小鼠中导致肥胖，并且每个基因都有对应的人类同源基因。其中一个基因编码由脂肪组织表达的信号，另一个编码该信号的脑受体。其余的基因揭示了可能位于该受体下游的脑内信号通路。这些基因共同展示了一个复杂的系统，该系统保护脂肪储备——并且在某些人身上维持着不健康的设定值。
