Kakinuma K, Tanaka R, Onda K, Takahashi H
Department of Neurosurgery, Niigata University, Japan.
Acta Neurochir (Wien). 1998;140(1):26-31; discussion 31-2. doi: 10.1007/s007010050053.
This study was designed to provide the reciprocal relationship among labelling indices of 5-bromodeoxyuridine (BUdR LI), Ki-67 (Ki-LI), and tumour doubling time (Td) of recurrent meningiomas. In our series of 182 primary intracranial meningiomas, 46 cases recurred. The average of BUdR LI and Ki LI for nonrecurrent meningiomas were 0.77 +/- 0.13% and 4.71 +/- 1.96%, respectively. Recurrent meningiomas had significantly higher LIs at the first operation: BUdR LI was 3.77 +/- 1.22% and Ki LI was 14.78 +/- 3.17%. The recurrent ratio significantly increased with the degrees of each LI. And the linear regression analysis has demonstrated a significant correlation between BUdR and Ki LI. Td was calculated accurately by NIH, a computer software. Td showed a significant inverse correlation with each of the labelling indices. Consequently, BUdR, Ki LIs and Td of individual tumours correlate mutually well. Of the 46 recurrent cases, 4 received radiation after the operation. Td of the irradiated meningiomas tended to be longer than expected for their higher level of BUdR and Ki LIs before radiation therapy. Thus, it was shown that the radiation therapy delays the regrowth of meningiomas.
本研究旨在探讨复发性脑膜瘤中5-溴脱氧尿苷标记指数（BUdR LI）、Ki-67（Ki-LI）与肿瘤倍增时间（Td）之间的相互关系。在我们的182例原发性颅内脑膜瘤系列中，有46例复发。非复发性脑膜瘤的BUdR LI和Ki LI平均值分别为0.77±0.13%和4.71±1.96%。复发性脑膜瘤在首次手术时的LI显著更高：BUdR LI为3.77±1.22%，Ki LI为14.78±3.17%。复发率随各LI程度显著增加。线性回归分析表明BUdR与Ki LI之间存在显著相关性。Td通过计算机软件NIH准确计算。Td与各标记指数均呈显著负相关。因此，单个肿瘤的BUdR、Ki LIs和Td相互之间相关性良好。在46例复发病例中，4例术后接受了放疗。放疗后脑膜瘤的Td往往比放疗前其较高水平的BUdR和Ki LIs所预期的要长。因此，表明放疗会延迟脑膜瘤的再生长。
