Ketkar V A, Kolling W M, Nardviriyakul N, VanDer Kamp K, Wurster D E
College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA.
Am J Health Syst Pharm. 1998 Mar 1;55(5):466-70. doi: 10.1093/ajhp/55.5.466.
The stability of adenosine in various diluents in polypropylene syringes and polyvinyl chloride (PVC) bags at three temperatures was studied. Portions of pooled undiluted adenosine infusion (3 mg/ mL) were stored in 60-mL capped syringes, 20 for each storage condition. Adenosine infusions were prepared by mixing adenosine with 5% dextrose injection, 0.9% sodium chloride injection, lactated Ringer's injection, or 5% dextrose and lactated Ringer's injection to produce a concentration of 0.75 mg/mL. Samples of each infusion were stored in 60-mL capped syringes and 50-mL bags, 20 syringes and 20 bags for each storage condition. Syringes and bags were stored in the dark at 25, 5, and -15 degrees C. At various sampling times, three syringes and three bags of each infusion were removed for visual inspection, pH measurement, and high-performance liquid chromatographic analysis. At 10 and 16 days, fungal growth at 25 degrees C was suspected in the infusions prepared with 5% dextrose injection. For all other samples, there was no evidence of precipitation or change in pH. The concentration of adenosine remained constant in all samples at all storage conditions. Adenosine 3 mg/mL was stable in polypropylene syringes for 7 days at 25 degrees C, 14 days at 5 degrees C, and 28 days at -15 degrees C; adenosine 0.75 mg/ mL in 0.9% sodium chloride injection and in 5% dextrose injection was stable in polypropylene syringes and PVC bags for 16 days at 25, 5, and -15 degrees C; and adenosine 0.75 mg/mL in lactated Ringer's injection and in 5% dextrose and lactated Ringer's injection was stable in syringes and bags for 14 days at 25, 5, and -15 degrees C.
研究了腺苷在三种温度下于聚丙烯注射器的各种稀释剂以及聚氯乙烯（PVC）袋中的稳定性。将部分混合的未稀释腺苷输注液（3毫克/毫升）储存在60毫升有盖注射器中，每种储存条件下20个。通过将腺苷与5%葡萄糖注射液、0.9%氯化钠注射液、乳酸林格氏注射液或5%葡萄糖和乳酸林格氏注射液混合来制备腺苷输注液，使其浓度达到0.75毫克/毫升。每种输注液的样本储存在60毫升有盖注射器和50毫升袋中，每种储存条件下20个注射器和20个袋子。注射器和袋子在25℃、5℃和 -15℃的黑暗环境中储存。在不同的采样时间，每种输注液取出三个注射器和三个袋子进行外观检查、pH值测量和高效液相色谱分析。在10天和16天时，怀疑用5%葡萄糖注射液制备的输注液在25℃下有真菌生长。对于所有其他样本，没有沉淀或pH值变化的迹象。在所有储存条件下，所有样本中腺苷的浓度保持恒定。3毫克/毫升的腺苷在25℃下于聚丙烯注射器中稳定7天，在5℃下稳定14天，在 -15℃下稳定28天；0.75毫克/毫升的腺苷在0.9%氯化钠注射液和5%葡萄糖注射液中，在25℃、5℃和 -15℃下于聚丙烯注射器和PVC袋中稳定16天；0.75毫克/毫升的腺苷在乳酸林格氏注射液以及5%葡萄糖和乳酸林格氏注射液中，在25℃、5℃和 -15℃下于注射器和袋子中稳定14天。
