Kinsella J P, Abman S H
Section of Neonatology, Children's Hospital, Denver, Colorado, USA.
Clin Perinatol. 1998 Mar;25(1):203-17.
Inhaled nitric oxide (NO) causes sustained improvement in oxygenation in near-term and term newborns with persistent pulmonary hypertension of the newborn (PPHN), and reduces the need for extracorporeal membrane oxygenation (ECMO). However, many questions remain concerning the application of inhaled NO to less severely ill infants, its use in units without immediate access to adjuvant therapies for hypoxemic respiratory failure, and in centers without ECMO. Particular vigilance must be given to the potential impact of widespread dissemination on inhaled NO therapy on time ECMO initiation, and the inappropriate use of inhaled NO in premature neonates.
吸入一氧化氮（NO）可使患有新生儿持续性肺动脉高压（PPHN）的近足月和足月新生儿的氧合持续改善，并减少体外膜肺氧合（ECMO）的使用需求。然而，关于吸入NO在病情较轻的婴儿中的应用、在无法立即获得低氧性呼吸衰竭辅助治疗的单位中的使用以及在没有ECMO的中心中的使用，仍存在许多问题。必须特别警惕吸入NO疗法的广泛传播对及时启动ECMO的潜在影响，以及早产新生儿不适当使用吸入NO的情况。
