Rivett A J
Department of Biochemistry, School of Medical Sciences, University of Bristol, UK.
Curr Opin Immunol. 1998 Feb;10(1):110-4. doi: 10.1016/s0952-7915(98)80040-x.
Proteasomes are large multicatalytic proteinase complexes which are responsible for the selective degradation of cellular proteins and the production of peptides for antigen presentation. Proteasomes are localized both in the nucleus and in the cytoplasm, where some are associated with the endoplasmic reticulum membrane. Recent studies have shown differences in the localization of proteasome subpopulations, demonstrated the functional importance of endoplasmic reticulum-associated proteasomes and investigated the role of putative nuclear localization signals and tyrosine phosphorylation on proteasome transport into the nucleus.
蛋白酶体是大型多催化蛋白酶复合物，负责细胞蛋白质的选择性降解以及用于抗原呈递的肽的产生。蛋白酶体定位于细胞核和细胞质中，其中一些与内质网膜相关。最近的研究显示了蛋白酶体亚群定位的差异，证明了内质网相关蛋白酶体的功能重要性，并研究了假定的核定位信号和酪氨酸磷酸化在蛋白酶体转运到细胞核中的作用。
