人类白细胞抗原匹配对慢性粒细胞白血病相关和无关供者移植治疗结局的影响。

Effect of HLA matching on outcome of related and unrelated donor transplantation therapy for chronic myelogenous leukemia.

作者信息

Petersdorf E, Anasetti C, Servida P, Martin P, Hansen J

机构信息

Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

出版信息

Hematol Oncol Clin North Am. 1998 Feb;12(1):107-21. doi: 10.1016/s0889-8588(05)70499-8.

DOI:10.1016/s0889-8588(05)70499-8

PMID:9523228

Abstract

This article examines the diversity and biologic role of human lymphocyte antigen (HLA) genes as related to marrow transplantation for chronic myelogenous leukemia (CML). A better understanding of the nature and function of HLA variation is necessary as unrelated marrow transplantation evolves into a safe and effective treatment for CML. HLA matching is an important aspect of donor selection criteria and has a role in engraftment as well as the development of graft-versus-host disease and tolerance after transplant.

摘要

本文探讨了人类淋巴细胞抗原（HLA）基因的多样性及其生物学作用，这些作用与慢性粒细胞白血病（CML）的骨髓移植相关。随着无关供体骨髓移植发展成为治疗CML的一种安全有效的方法，更深入地了解HLA变异的本质和功能是很有必要的。HLA配型是供体选择标准的一个重要方面，在移植后的植入以及移植物抗宿主病的发生和免疫耐受方面都发挥着作用。