Crout N M, Mayes R W, Beresford N A, Lamb C S, Howard B J
Department of Physiology and Environmental Science, University of Nottingham, Sutton Bonington, UK.
Radiat Environ Biophys. 1998 Feb;36(4):243-50. doi: 10.1007/s004110050078.
The results of a study in which groups of sheep were given single oral administrations of 14C, 3H and 35S and then slaughtered over a period of 1 year are reported. The experimental data were used to investigate the potential of metabolically based models for describing the transfer of the three radionuclides to sheep tissues. The structure of these models is based upon a simplified understanding of the transfer of the macro-elements C, H and S by processes such as respiration and protein synthesis/degradation. A consequence of this approach is that the three models have many common parameters. The models reproduced the general trends of the observations, accounting for 74%, 66%, and 58% of the observed variation in the 14C, 3H and 35S data, respectively, suggesting that they may provide a useful alternative approach to modelling the transfer of these radionuclides. The models presented are limited to the particular experimental situation for which they were developed, and further experimental work would be required to extend them. However, such metabolically based models have great potential: for example, they should be able to account for the influence of dietary intake, physiological status or the form of the radionuclide in the animals diet (e.g. tritiated water or organically bound tritium).
报告了一项研究结果，该研究将绵羊分组，单次口服给予14C、3H和35S，然后在1年的时间内进行屠宰。实验数据用于研究基于代谢的模型描述这三种放射性核素向绵羊组织转移的潜力。这些模型的结构基于对通过呼吸和蛋白质合成/降解等过程实现的宏量元素C、H和S转移的简化理解。这种方法的一个结果是这三个模型有许多共同参数。这些模型再现了观测结果的总体趋势，分别解释了14C、3H和35S数据中观测到的变异的74%、66%和58%，表明它们可能为模拟这些放射性核素的转移提供一种有用的替代方法。所提出的模型仅限于为其开发的特定实验情况，需要进一步的实验工作来扩展它们。然而，这种基于代谢的模型有很大潜力：例如，它们应该能够解释饮食摄入、生理状态或动物饮食中放射性核素形式（如氚化水或有机结合氚）的影响。
