Galeriu D, Beresford N A, Takeda H, Melintescu A, Crout N M J
National Institute for Physics and Nuclear Engineering, PO Box MG-6 RO-76900, Bucharest-Magurele, Romania.
Radiat Prot Dosimetry. 2003;105(1-4):387-90. doi: 10.1093/oxfordjournals.rpd.a006264.
Available data have been analysed to test the hypothesis that both 3H and 14C transfer in mammals can be accounted for by an understanding of metabolism. Data obtained from various 14C and 3H experiments with rats and sheep have been analysed to assess the multi-component retention function of various organs and identify any relationship between half-times and component contribution. Our hypothesis was that component half-times for 14C and 3H are similar after intakes of organic compounds. Similarities in the tritium and carbon dynamics between rat and sheep were observed supporting the hypothesis. For fast and slow components of muscle half-time, allometric relationships have been derived. The results obtained could be used in the development of a human biokinetic model.
已对现有数据进行分析，以检验这样一种假设：通过对新陈代谢的理解可以解释哺乳动物体内的³H和¹⁴C转移。对从大鼠和绵羊的各种¹⁴C和³H实验中获得的数据进行了分析，以评估各器官的多组分滞留功能，并确定半衰期与组分贡献之间的任何关系。我们的假设是，摄入有机化合物后，¹⁴C和³H的组分半衰期相似。观察到大鼠和绵羊之间氚和碳动力学的相似性，支持了这一假设。对于肌肉半衰期的快速和慢速组分，已得出异速生长关系。所获得的结果可用于开发人体生物动力学模型。
