Nagl U O, Erdel M, Bergmann F, Oehl B, Scandella E, Musante L, Galietta L J, Gschwentner M, Fürst J, Schmarda A, Hofer S, Utermann G, Deetjen P, Paulmichl M
Department of Physiology, University of Innsbruck, Fritz-Pregl-Strasse 3, A-6020, Innsbruck, Austria.
Gene. 1998 Mar 16;209(1-2):59-63. doi: 10.1016/s0378-1119(98)00002-x.
Expression cloning revealed a chloride channel (ICln) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human ICln-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A.
