Trpkov K, Abdulkareem F, Jim K, Solez K
Department of Laboratory Medicine and Pathology, University of Alberta Hospital, Edmonton, Canada.
Clin Nephrol. 1998 Feb;49(2):124-8.
A patient developed recurrent anti-glomerular basement membrane (GBM) antibody (ab) disease after twelve years of an uneventful posttransplant course, clinically accompanied by rapidly rising creatinine. He additionally exhibited coexisting IgA nephropathy at the time of the reappearing anti-GBM disease. Both linear IgG and mesangial IgA were detected by immunofluorescence, and electron microscopy demonstrated mesangial immune complex deposits. To our knowledge, the association of anti-GBM ab disease and IgA nephropathy has not been reported previously.
一名患者在移植后经历了十二年的平稳病程后，出现了复发性抗肾小球基底膜（GBM）抗体（ab）疾病，临床上伴有肌酐迅速升高。在再次出现抗GBM疾病时，他还同时患有IgA肾病。免疫荧光检测到线性IgG和系膜IgA，电子显微镜显示系膜免疫复合物沉积。据我们所知，抗GBM ab疾病与IgA肾病的关联此前尚未见报道。
