Hirono N, Mori E, Ishii K, Ikejiri Y, Imamura T, Shimomura T, Ikeda M, Yamashita H, Takatsuki Y, Sasaki M
Department of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders, Himeji, Japan.
Dement Geriatr Cogn Disord. 1998 Mar-Apr;9(2):68-73. doi: 10.1159/000017025.
To elucidate the nature of language disturbance in Alzheimer's disease (AD) and the cerebral area involved in it, we studied 65 AD patients with the Western Aphasia Battery (WAB) and with 18F-fluorodeoxyglucose and positron emission tomography. Partial correlations were evaluated between the Aphasia Quotient of WAB and regional cerebral glucose metabolism normalized by the mean metabolic rate in the bilateral primary sensorimotor areas after controlling age, sex, education and severity of illness. Language disturbance in AD is accounted for by deficits in the semantic processing of language and is related to glucose hypometabolism in the inferior temporal gyrus and inferior parietal lobule, especially in the dominant side. These results offer further evidence suggesting that the lexico-semantic processing system is mediated in these regions.
为了阐明阿尔茨海默病（AD）中语言障碍的本质及其所涉及的脑区，我们使用西方失语症成套测验（WAB）以及18F-氟脱氧葡萄糖和正电子发射断层扫描对65例AD患者进行了研究。在控制年龄、性别、教育程度和疾病严重程度后，评估WAB失语商与经双侧初级感觉运动区平均代谢率标准化后的局部脑葡萄糖代谢之间的偏相关性。AD中的语言障碍是由语言语义处理缺陷引起的，并且与颞下回和顶下小叶的葡萄糖代谢减低有关，尤其是优势侧。这些结果提供了进一步的证据，表明词汇语义处理系统在这些区域中发挥作用。
