患有白细胞黏附缺陷的小母牛中输注的CD18阳性粒细胞的存活及其化学发光反应

Survival of transfused CD18-positive granulocytes and their chemiluminescent response in a heifer with leukocyte adhesion deficiency.

作者信息

Nagahata H, Sakurai N, Matsuki S, Miura T, Nioka K, Kociba G J

机构信息

Department of Animal Health, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.

出版信息

J Vet Med Sci. 1998 Feb;60(2):261-2. doi: 10.1292/jvms.60.261.

DOI:10.1292/jvms.60.261

PMID:9524955

Abstract

Granulocyte transfusion (GT) was performed in an 8-month-old heifer with leukocyte adhesion deficiency (BLAD) to monitor the changes in transfused CD18-positive neutrophils and associated neutrophil chemiluminescent (CL) response in beta 2-integrin-deficient host. The CD18-positive neutrophils were detected in blood from the BLAD heifer during the first 3 hr after 2.6 x 10(9) cells were infused by GT, and disappeared by 5 hr after GT. The CL response of neutrophils was increased 1.7 to 2.8-fold in the BLAD heifer during the first 3 hr after GT, thereafter CL response decreased gradually from 2 to 5 hr after GT.

摘要

对一头患有白细胞黏附缺陷（BLAD）的8月龄小母牛进行了粒细胞输注（GT），以监测β2整合素缺陷宿主中输注的CD18阳性中性粒细胞的变化以及相关的中性粒细胞化学发光（CL）反应。在通过GT输注2.6×10⁹个细胞后的最初3小时内，在BLAD小母牛的血液中检测到了CD18阳性中性粒细胞，并在GT后5小时消失。GT后最初3小时内，BLAD小母牛中性粒细胞的CL反应增加了1.7至2.8倍，此后CL反应在GT后2至5小时逐渐下降。