Leung V P, Chiu H F, Lam L C
Department of Psychiatry, Chinese University of Hong Kong.
Pharmacopsychiatry. 1998 Jan;31(1):32-4. doi: 10.1055/s-2007-979293.
Hyponatremia is an uncommon but widely reported complication of selective serotonin uptake inhibitors (SSRIs), and most of the case reports involve elderly patients. The presentation is usually that of SIADH, but the underlying mechanism leading to the syndrome is poorly understood. Since the use of SSRIs is becoming more popular among elderly depressed patients and because of the potentially serious consequence of hyponatremia, psychiatrists should be alert to the development of the complication and familiarize themselves with its diagnosis and treatment. We report two elderly patients who were identified to have hyponatremia after the commencement of paroxetine. This illustrates the need for monitoring of plasma sodium level if a patient's clinical condition deteriorates. Other factors possibly related to the hyponatremia are discussed and a review of the diagnosis and management of SSRI-related hyponatremia is included.
低钠血症是选择性5-羟色胺再摄取抑制剂（SSRI）一种虽不常见但被广泛报道的并发症，大多数病例报告涉及老年患者。其临床表现通常为抗利尿激素分泌异常综合征（SIADH），但导致该综合征的潜在机制尚不清楚。由于SSRI在老年抑郁症患者中使用越来越普遍，且低钠血症可能产生严重后果，精神科医生应警惕该并发症的发生，并熟悉其诊断和治疗方法。我们报告了两名老年患者，在开始服用帕罗西汀后被发现患有低钠血症。这表明，如果患者临床状况恶化，需要监测血浆钠水平。文中还讨论了可能与低钠血症相关的其他因素，并对SSRI相关低钠血症的诊断和管理进行了综述。
