Odeh M, Seligmann H, Oliven A
Department of Internal Medicine B, Bnai Zion Medical Center, Haifa, Israel.
J Clin Pharmacol. 1999 Dec;39(12):1290-1. doi: 10.1177/00912709922011980.
Hyponatremia secondary to the syndrome of inappropriate secretion of antiduretic hormone (SIADH) is an uncommon complication of treatment with the antidepressants the selective serotonin reuptake inhibitors (SSRIs). These effective anti-depressant agents are becoming widely used because of their favorable side effect profile and their safety in overdose. Although most reports have implicated fluoxetine in causing hyponatremia, there have also been a few reports of hyponatremia associated with paroxetine. We describe an elderly patient with severe life-threatening hyponatremia in association with paroxetine therapy. The present case and the others previously reported emphasize the need for greater awareness of the development of this serious and potentially fatal complication, and suggest that serum sodium concentration should be measured periodically in elderly patients soon after they start taking any agent of the SSRIs, especially during the first 2 to 4 weeks of treatment.
抗利尿激素分泌不当综合征（SIADH）继发的低钠血症是抗抑郁药选择性5-羟色胺再摄取抑制剂（SSRIs）治疗中一种不常见的并发症。这些有效的抗抑郁药因其良好的副作用表现及过量服用时的安全性而被广泛使用。尽管大多数报告认为氟西汀可导致低钠血症，但也有一些关于帕罗西汀相关低钠血症的报道。我们描述了一名老年患者，其在接受帕罗西汀治疗时出现了严重的、危及生命的低钠血症。本病例及之前报道的其他病例强调了需要更重视这种严重且可能致命的并发症的发生，并建议老年患者在开始服用任何一种SSRIs药物后不久，尤其是在治疗的前2至4周，应定期测量血清钠浓度。
