Ponomareva T R, Smolianskaia A Z
Antibiotiki. 1976 Jul;21(7):604-8.
Occurrence of the markers of penicillin and erythromycin resistance in the clinical strains of Staph. aureus, as well as their connection with the determinants of resistance to the heavy metal salts and sodium arsenate was studied. 79 per cent of Staph. aureus were resistant to penicillin and 47 per cent to erythromycin. All erythromycin resistant strains were also resistant to penicillin. More than a half of the strains of Staph. aureus of the phage groups I, III and the mixed phage group had a set of markers: pen, asa, cad, mer, ego. The rate of elimination of the above markers with ethidium bromide was high. The presence of the penicillinase plasmid determining a rather low level of resistance to erythromycin (20--50 gamma/ml) was characteristic of the strains belonging to the phage group I. The presence of the plasmid determining a high level of resistance to that drug (500--1000 gamma/ml) was characteristic of the phage group III and the mixed phage group. The erythromycin sensitive strains of Staph. aureus were almost always sensitive to mercuric ions.
研究了金黄色葡萄球菌临床菌株中青霉素和红霉素抗性标记的出现情况，以及它们与重金属盐和砷酸钠抗性决定因素之间的联系。79%的金黄色葡萄球菌对青霉素耐药，47%对红霉素耐药。所有对红霉素耐药的菌株也对青霉素耐药。噬菌体I组、III组和混合噬菌体组的一半以上金黄色葡萄球菌菌株具有一组标记：pen、asa、cad、mer、ego。用溴化乙锭消除上述标记的速率很高。决定对红霉素耐药水平较低（20 - 50微克/毫升）的青霉素酶质粒的存在是噬菌体I组菌株的特征。决定对该药物高耐药水平（500 - 1000微克/毫升）的质粒的存在是噬菌体III组和混合噬菌体组的特征。金黄色葡萄球菌的红霉素敏感菌株几乎总是对汞离子敏感。
