Ivanov K S, Netsvetaev A V, Finogeev Iu P, Marchuk V I
Antibiotiki. 1976 Jul;21(7):617-21.
The effect of hydrocortisone on kanamycin pharmacokinetics in rabbits treated with the drugs administered intramuscularly in two different syringes simultaneously and in one syringe was studied. When the drugs were administered in two different syringes, there were no changes in the antibiotic pharmacokinetics as compared to the control group, while administration of the drugs in one syringe resulted in decreased excretion of the antibiotic with urine and a significant increase of its levels in the blood, liquor and tissues.
研究了氢化可的松对家兔卡那霉素药代动力学的影响，家兔同时用两个不同注射器或一个注射器肌肉注射这两种药物。当用两个不同注射器给药时，与对照组相比，抗生素药代动力学没有变化，而用一个注射器给药则导致抗生素尿排泄减少，血液、脑脊液和组织中药物水平显著升高。
