醋酸甲羟孕酮（MPA）对N-甲基-N-亚硝基脲（MNU）诱导的BALB/c小鼠乳腺肿瘤的启动作用。

Promoter effect of medroxyprogesterone acetate (MPA) in N-methyl-N-nitrosourea (MNU) induced mammary tumors in BALB/c mice.

作者信息

Pazos P, Lanari C, Elizalde P, Montecchia F, Charreau E H, Molinolo A A

机构信息

Instituto de Biologia y Medicina Experimental, Academia Nacional de Medicina, Buenos Aires, Argentina.

出版信息

Carcinogenesis. 1998 Mar;19(3):529-31. doi: 10.1093/carcin/19.3.529.

DOI:10.1093/carcin/19.3.529

PMID:9525291

Abstract

The promoter effect of medroxyprogesterone acetate (MPA) on mammary carcinogenesis in female BALB/c mice was investigated using methylnitrosourea (MNU) as initiator. Nine out of 43 animals developed mammary carcinomas in the group treated with MNU (50 mg/kg) and MPA (administration of 40 mg every 3 months) starting 1 week after MNU administration. No tumors appeared in controls receiving only MNU or MPA during the time course of the experiment (9 months). The tumors were lobular adenocarcinomas showing different degrees of squamous differentiation with low or undetectable estrogen and progesterone receptors, and expressing epidermal growth factor receptors. These results support the hypothesis that MPA promotes the growth of MNU induced lesions.

摘要

以甲基亚硝基脲（MNU）作为引发剂，研究了醋酸甲羟孕酮（MPA）对雌性BALB/c小鼠乳腺癌发生的促进作用。在MNU给药（50 mg/kg）后1周开始，用MNU和MPA（每3个月给予40 mg）处理的43只动物中有9只发生了乳腺癌。在实验过程（9个月）中，仅接受MNU或MPA的对照组未出现肿瘤。肿瘤为小叶腺癌，显示不同程度的鳞状分化，雌激素和孕激素受体含量低或检测不到，并表达表皮生长因子受体。这些结果支持MPA促进MNU诱导损伤生长这一假说。