Kelly R, Davidson G P, Townley R R, Campbell P E
Arch Dis Child. 1976 Mar;51(3):219-22. doi: 10.1136/adc.51.3.219.
In 3 cases of acrodermatitis enteropathica duodenal biopsy performed at the outset of treatment showed a similar abnormality of the intestinal mucosa. Further biopsies taken during treatment showed progressive improvement of the intestinal mucosa with subsequent complete restoration of the normal cellular and villous pattern. The initial treatment was with expressed human breast milk and oral di-iodohydroxyquinoline. The latter was continued alone and later replaced by zinc sulphate. Changes in the intestinal epithelial cells and inflammatory cell infiltration of the lamina propria still detectable on di-iodohydroxyquinoline therapy reverted to normal with oral zinc.
在3例肠病性肢端皮炎患者中，治疗开始时进行的十二指肠活检显示肠黏膜存在类似异常。治疗期间进行的进一步活检显示肠黏膜逐渐改善，随后正常细胞和绒毛模式完全恢复。初始治疗采用挤出的人母乳和口服二碘羟基喹啉。后者单独持续使用，后来被硫酸锌替代。在二碘羟基喹啉治疗时仍可检测到的肠上皮细胞变化和固有层炎症细胞浸润，在口服锌后恢复正常。
