Spirer Z, Shalit I, Zakuth V, Svirsky-Fein S, Milbauer B, Bogair N
Arch Dis Child. 1976 Mar;51(3):231-3. doi: 10.1136/adc.51.3.231.
Twenty-one preterm and 23 term neonates, 13 splenectomized children and one with congenital asplenia, and 20 normal children were examined for plasma antihaemophilic activity and for blood leucocyte levels before and 30 minutes after a subcutaneous injection of epinephrine 0-01 mg/kg. The basal values for antihaemophilic activity were similar for the 4 groups. The response to epinephrine was a trivial rise in antihaemophilic activity in the preterm group, while the rise in the term newborns was comparable to that of the normal children. The asplenic children all showed a trivial rise. The leucocyte response was also negligible in both the preterm neonates and asplenic groups, while in the term infants it was comparable to that seen in the normal children. These results may indicate an incapacity of the preterm newborn infant's reticuloendothelial system and spleen to react to other challenges, such as bacterial infection.
对21名早产儿、23名足月儿、13名脾切除儿童、1名先天性无脾儿童以及20名正常儿童，在皮下注射0.01mg/kg肾上腺素前及注射后30分钟，检测其血浆抗血友病活性及血液白细胞水平。4组的抗血友病活性基础值相似。早产儿组对肾上腺素的反应是抗血友病活性轻微升高，而足月儿的升高幅度与正常儿童相当。无脾儿童均表现为轻微升高。早产儿组和无脾组的白细胞反应也可忽略不计，而足月儿的反应与正常儿童相当。这些结果可能表明早产儿的网状内皮系统和脾脏无法对其他挑战（如细菌感染）作出反应。
